Juvenile rheumatoid arthritis, which is also called juvenile idiopathic arthritis or JIA, is an autoimmune disease that affects children. Learn about the symptoms, causes, treatment, and outlook here.
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DDAVP and von Willebrand disease
How does DDAVP work in the treatment of von Willebrand disease?
DDAVP is a synthetic analog of vasopressin, the antidiuretic hormone. Within 1 to 2 hours of its administration (either intravenous, subcutaneous, or intranasal), plasma vWF levels increase by 2-fold to 8-fold. DDAVP appears to act by causing the release of vWF from the endothelial cells. Factor VIII levels also increase in part because of the increased stabilization of vWF/factor VIII complex by DDAVP, which lessens proteolytic degradation. As a caution, DDAVP administration in the setting of von Willebrand disease type IIB may cause a dangerous drop in platelet count due to increased vWF binding and platelet clearance.
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