Dexamethasone: Idiopathic Thrombocytopenic Purpura in Children and Adolescents
Indication:
Children and adolescents (age range, 3 to 17 years) with persistent or chronic refractory ITP.
Dosage and duration:
Guidelines have provided varied oral dosage regimens for dexamethasone in the management of ITP, including 28 to 40 mg/m2/day, without specifying duration or cyclic high-dose regimens (0.6 mg/kg/day for 4 days every 4 weeks for 6 cycles).
Small prospective trials have documented oral dosage regimens as 20 mg/m2 daily (in 2 divided doses) for 4 days every 4 weeks for a total of 6 cycles/courses or 0.6 mg/kg daily for 4 consecutive days once a month for 6 courses.
Intravenous
Administered as 20 mg/m2 daily for 4 days. A cycle was administered every 15 days for a total of 4 courses.
You can read full article at
No comments:
Post a Comment